valPure® NBPA Epoxy Studies and Research

Studies/Research

During the early phases of the valPure V70 ideation, Sherwin-Williams developed and adopted the 7-step Safety by Design process. Safety by Design incorporates a variety of testing including studies intended for global regulatory compliance and hypothesis-driven scientific research to promote innovation.

Regulatory compliance studies are performed by contract research organizations in accordance with widely accepted guidelines under good laboratory practice (GLP) conditions. These studies include toxicology testing of acute, sub-chronic, and chronic toxicology; reproductive and developmental toxicology; genotoxicity and mutagenicity; ecotoxicology; and environmental fate studies. Often the results from regulatory studies are presented and disseminated as study reports.

To accompany regulatory compliance studies, Sherwin-Williams supports hypothesis-driven scientific research to promote innovation of the valPure V70 technology. This research is primarily conducted by academic institutions who are given full autonomy. Sherwin-Williams supported research includes further investigation into specific pathways including endocrine activity, immune system modulation, and environmental impact. These research studies are published in reputable peer-reviewed journals.

As a commitment to transparency, Sherwin-Williams has made all study reports and scientific research publications available via links which are provided below. The collection of study reports and scientific publications represents more than a decade’s worth of V70 research and development.

Scientific Research Publications

• Study published in Environmental Science & Technology, "Evidence of absence: estrogenicity assessment of a new food-contact coating and the bisphenol used in its synthesis" Soto AM, Schaeberle C, Maier MS, Sonnenschein C, Maffini MV. (2017)"
• Food Packaging Forum published, "High throughput in vitro testing of BPA anlogues"
• Study published in PLoS One, "Characterizing properties of non-estrogenic substituted bisphenol analogs using high throughput microscopy and image analysis." Szafran AT, Stossi F, Mancini MG, Walker CL, Mancini MA. (2017).  
• Food and Chemical Toxicology published, "An expanded toxicological profile of tetramethyl bispheno F (TMBPF), a precursor for a new food-contact metal packaging coating."Maffini MV, Canatsey RD. (2019)
• Food and Chemical Toxicology published, "Characterization of a new polymeric food contact coating with emphasis on the chemical analysis and safety assessment of non-intentionally added substances (NIAS)." Thomas R. Mallen , Kadijah D. Abston , Nathanial J. Parizek , Judith Negley , Kevin S. Shores , Ryan D. Canatsey , Sarah Dubail , Mark S. Maier , Maricel V. Maffini (2023)

Other Publications

• Green Chemistry Letters and Reviews published, "The nexus between alternatives assessment and green chemistry: supporting the development and adoption of safer chemicals" Joel A. Tickner , Rachel V. Simon , Molly Jacobs , Lindsey D. Pollard & Saskia K. van Bergen (2021) , Green Chemistry Letters and Reviews, 14:1, 21-42, DOI:10.1080/17518253.2020.1856427